Pamidronate Injection : Uses, Side Effects, Interactions & More

Why is this medication prescribed?
Pamidronate is used to treat high levels of calcium in the blood that can be caused by certain types of cancer. Pamidronate is also used in conjunction with cancer chemotherapy to treat bone damage caused by multiple myeloma (cancer that begins in plasma cells [a type of white blood cell that produces substances necessary to fight infection] ) or cancer of breast that has spread to the bones. Pamidronate is also used to treat Paget’s disease (a condition in which the bones are soft and weak and can easily deform, hurt, or break). Pamidronate injection belongs to a class of medications called bisphosphonates. It works by slowing bone breakdown, increasing bone density (thickness), and decreasing the amount of calcium released from the bones into the blood.

How should this medicine be used?
Pamidronate injection comes as a solution (liquid) to inject into a vein slowly, over 2 to 24 hours. It is usually injected by a healthcare provider in a doctor’s office, hospital, or clinic. It can be administered once every 3 to 4 weeks, once a day for 3 days in a row, or as a single dose that can be repeated after 1 week or more. The treatment schedule depends on your condition.

Your doctor may recommend a calcium supplement and a multivitamin containing vitamin D to take during your treatment. You should take these supplements every day as directed by your doctor.

Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before receiving Pamidronate Injection,

  • Tell your doctor and pharmacist if you are allergic to pamidronate, alendronate (Fosamax), etidronate (Didronel), risedronate (Actonel), tiludronate (Skelid), any other medications, or any of the ingredients. of pamidronate injection. Ask your pharmacist for a list of the ingredients.
  • Tell your doctor and pharmacist what prescription and over-the-counter medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: cancer chemotherapy drugs; oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol) and prednisone (Deltasone), and thalidomide (Thalomid). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications can also interact with pamidronate injection, so be sure to tell your doctor about all the medications you are taking, even those that are not listed here.
  • Tell your doctor if you are receiving radiation therapy and if you have had or have ever had thyroid surgery, seizures, or liver or kidney disease.
  • Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. You must use a reliable method of contraception to prevent pregnancy while receiving pamidronate. If you become pregnant while receiving pamidronate, call your doctor immediately. Talk to your doctor if you plan to become pregnant at any time in the future because pamidronate may remain in your body for years after you stop using it.
  • You should know that pamidronate can cause serious jaw problems, especially if you have dental surgery or treatment while you are taking the medicine. A dentist should examine your teeth and perform the necessary treatments before you start receiving pamidronate. Be sure to brush your teeth and clean your mouth properly while receiving pamidronate. Talk to your doctor before undergoing any dental treatment while you are receiving this medicine.
  • You should know that pamidronate injection can cause severe pain in your bones, muscles, or joints. You may begin to feel this pain days, months, or years after receiving the pamidronate injection for the first time. Although this type of pain may start after receiving pamidronate injection for some time, it is important for you and your doctor to realize that it may be caused by pamidronate. Call your doctor immediately if you experience severe pain at any time during your treatment with pamidronate injection. Your doctor may stop giving you pamidronate injection and your pain may go away after stopping treatment with this medicine.

What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet

What should I do if I forget a dose?
Call your doctor if you miss a dose of pamidronate or an appointment to receive a dose of pamidronate.

What side effects can this medication cause?

Pamidronate injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • redness, swelling, or pain in the injection spot
  • stomach pain
  • loss of appetite
  • constipation
  • nausea
  • vomiting
  • heartburn
  • change in ability to taste food
  • sores in the mouth
  • fever
  • headache
  • dizziness
  • excessive tiredness
  • difficulty falling asleep or staying asleep
  • coughing
  • difficulty urinating or painful urination
  • swelling of the hands, arms, feet, ankles, or lower legs

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

  • painful or swollen gums
  • loosening of the teeth
  • numbness or heavy feeling in the jaw
  • poor healing of the jaw
  • vomit that is bloody or looks like coffee grounds
  • bloody or black and tarry stools
  • shortness of breath
  • fast heartbeat
  • fainting
  • sudden tightening of muscles
  • numbness or tingling around the mouth
  • eye pain or tearing

Pamidronate injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medicine.

If you experience a serious side effect, you or your doctor can submit an online report to the Food and Drug Administration (FDA) MedWatch Adverse Event Reporting Program ( or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?
If you are giving this medicine at home, your healthcare provider will tell you how to store it. Follow these instructions carefully.

Unnecessary medications must be disposed of in a special way to ensure that pets, children and others cannot consume them. However, you should not flush this medicine down the toilet. Instead, the best way to get rid of your medication is through a medication take-back program. Talk to your pharmacist or contact your local garbage / recycling department for information on return programs in your community. Consult the FDA’s Safe Drug Disposal website ( for more information if you do not have access to a take-back program.

In case of emergency/overdose
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim collapsed, had a seizure, is having trouble breathing, or cannot wake up, call 911 immediately.

Symptoms of overdose may include:

  • fever
  • change in ability to taste food
  • sudden tightening of the muscles
  • numbness or tingling around the mouth

What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain laboratory tests to check your body’s response to the pamidronate injection.

It is important to keep a written list of all prescription and over-the-counter (non-prescription) medications you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should carry this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Brand Names

  • Aredia

Other Names

  • ADP Sodium
  • AHPrBP Sodium

Disclaimer: We have made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.

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