Netupitant and Palonosetron : Uses, Side Effects, Interactions & More

Why is this medication prescribed?

The combination of netupitant and palonosetron is used to prevent nausea and vomiting caused by cancer chemotherapy. Netupitant belongs to a class of drugs called neurokinin (NK1) antagonists. It works by blocking neurokinin, a natural substance in the brain that causes nausea and vomiting. Palonosetron is in a class of medications called 5-HT3 receptor antagonists. It works by blocking serotonin, a natural substance in the body that causes nausea and vomiting.

How should this medicine be used?

The combination of netupitant and palonosetron comes as capsules to take by mouth. It is usually taken about 1 hour before the start of chemotherapy with or without food. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any parts you don’t understand. Take netupitant and palonosetron exactly as directed. Do not take more or less, or take it more often than prescribed by your doctor.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking netupitant and palonosetron,

  • Tell your doctor and pharmacist if you are allergic to netupitant and palonosetron, alosetron (Lotronex), dolasetron (Anzemet), granisetron (Sancuso), ondansetron (Zofran, Zuplenz), any other medications, or any of the ingredients in netupitant capsules. and palonosetron. Ask your pharmacist for a list of the ingredients.
  • Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: benzodiazepines including alprazolam (Xanax), midazolam, and triazolam (Halcion); certain chemotherapy drugs such as cyclophosphamide (Cytoxan), docetaxel (Docefrez, Taxotere), etoposide, ifosfamide (Ifex), imatinib (Gleevec), irinotecan (Camptosar), paclitaxel (Taxol), vinblastine, vincristorel, and vinblastine, vincristorel, and navellbine navelbine (Navelbine vin) dexamethasone; erythromycin (E.E.S., Ery-tab, others); fentanyl (Abstral, Actiq, Duragesic, Fentora, Lazanda, Onsolis, Subsys); ketoconazole (Nizoral); lithium (Lithobid); medications to treat migraines, such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), and zolmitriptan (Zomig); Methylene blue; mirtazapine (Remeron); monoamine oxidase (MAO) inhibitors including isocarboxazid (Marplan), linezolid (Zyvox), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate); phenobarbital; rifampicin (Rifadin, Rimactane, in Rifater, in Rifamate); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); and tramadol (Conzip, Ultram, in Ultracet). Your doctor may need to change the doses of your medications or monitor you closely for side effects.
  • Tell your doctor if you have or have ever had liver or kidney disease.
  • Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking netupitant and palonosetron, call your doctor.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

Netupitant and palonosetron should only be taken before chemotherapy as directed by your doctor. It should not be taken on a regular basis.

What side effects can this medication cause?

Netupitant and palonosetron may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • headache
  • stomach pain
  • heartburn
  • constipation
  • weakness
  • redness of the skin

Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately or seek emergency medical treatment:

  • hives
  • rash
  • itching
  • difficulty breathing or swallowing
  • shortness of breath
  • dizziness, lightheadedness, and fainting
  • fast, slow or irregular heartbeat
  • agitation
  • hallucinations (seeing things or hearing voices that do not exist)
  • fever
  • flushing
  • excessive sweating
  • confusion
  • nausea, vomiting, and diarrhea
  • loss of coordination
  • stiff or twitching muscles
  • seizures
  • coma (loss of consciousness)

Netupitant and palonosetron may cause other side effects. Call your doctor if you have any unusual problems while taking this medicine.

If you experience a serious side effect, you or your doctor can submit a report online to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medicine in the container it came in, tightly closed, and out of the reach of children. Store at room temperature and away from light, excess heat, and moisture (not in the bathroom). Throw away any medicine that is out of date or no longer needed. Talk to your pharmacist about the correct way to dispose of your medicine.

It is important to keep all medicines out of the sight and reach of children, since many containers (such as those containing weekly pills and those for eye drops, creams, patches and inhalers) are not child-resistant and small children can easily open them. To protect young children from poisoning, always close the safety caps and immediately place the medicine in a safe place, one that is upright and out of their sight and reach. http://www.upandaway.org

What other information should I know?

Keep all your appointments with your doctor.

Do not let anyone else take your medicine.

It is important that you keep a written list of all prescription and over-the-counter (over-the-counter) medications you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should take this list with you every time you visit a doctor or if you go into hospital. It is also important information to take with you in case of emergencies.

Brand Names

  • Akynzeo®

Disclaimer: We have made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.

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