Motrin : Uses, Side Effects, Interactions & More

People taking nonsteroidal anti-inflammatory drugs (NSAIDs) (other than aspirin) such as Motrin may have a higher risk of having a heart attack or stroke than people who do not take these drugs. These events can occur without warning and can cause death. This risk may be higher for people who take NSAIDs for a long time. Do not take an NSAID like Motrin if you have recently had a heart attack, unless your doctor tells you to. Tell your doctor if you or someone in your family has or has ever had heart disease, a heart attack, or a stroke; if you smoke and if you have or have had high cholesterol, high blood pressure or diabetes. Get emergency medical help right away if you experience any of the following symptoms: chest pain, shortness of breath, weakness in one part or side of the body, or trouble speaking.

If you are going to have a coronary artery bypass (CABG; a type of heart surgery), you should not take Motrin just before or just after surgery.

NSAIDs like Motrin can cause ulcers, bleeding, or holes in the stomach or intestine. These problems can develop at any time during treatment, can occur without warning symptoms, and can be fatal. The risk may be higher for people who take NSAIDs for a long time, are older in age, have health problems, or drink three or more alcoholic beverages per day while taking Motrin. Tell your doctor if you take any of the following medications: blood thinners (‘blood thinners’) such as warfarin (Coumadin, Jantoven); aspirin; other NSAIDs such as ketoprofen and naproxen (Aleve, Naprosyn); oral steroids such as dexamethasone, methylprednisolone (Medrol) and prednisone (Rayos); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), fluoxetine (Prozac, Sarafem, Selfemra, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva) and sertraline (Zoloft); or serotonin norepinephrine reuptake inhibitors (SNRIs) such as desvenlafaxine (Khedezla, Pristiq), duloxetine (Cymbalta), and venlafaxine (Effexor XR). Also tell your doctor if you have or have ever had ulcers, bleeding in the stomach or intestines, or other bleeding disorders. If you experience any of the following symptoms, stop taking Motrin and call your doctor: stomach pain, heartburn, vomit that is bloody or looks like coffee grounds, blood in the stool, or black, tarry stools.

Keep all appointments with your doctor and the laboratory. Your doctor will monitor your symptoms carefully and will probably order certain tests to check your body’s response to Motrin. Be sure to tell your doctor how you feel so your doctor can prescribe the correct amount of medication to treat your condition with the least risk of serious side effects.

Your doctor or pharmacist will provide you with the manufacturer’s patient information sheet (Medication Guide) when you start your prescription Motrin treatment and each time you get a refill. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website ( or the manufacturer’s website to obtain the Medication Guide.

Why is this medication prescribed?
Prescription Motrin (Ibuprofen) is used to relieve pain, tenderness, swelling, and stiffness caused by osteoarthritis (arthritis caused by a rupture of the joint lining) and rheumatoid arthritis (arthritis caused by swelling of the joint lining) . It is also used to relieve mild to moderate pain, including menstrual pain (pain that occurs before or during a menstrual period). Over-the-counter Motrin is used to reduce fever and relieve minor aches and headaches, muscle aches, arthritis, menstrual periods, the common cold, toothache, and back pain. Motrin belongs to a class of medications called NSAIDs. It works by stopping the body’s production of a substance that causes pain, fever, and inflammation.

How should this medicine be used?
Prescription Motrin (Ibuprofen) comes as a tablet to take by mouth. It is usually taken three to four times a day for arthritis or every 4 to 6 hours as needed for pain. Over-the-counter Motrin comes in tablets, chewable tablets, suspension (liquid) and drops (concentrated liquid). Adults and children over the age of 12 can generally take Motrin without a prescription every 4 to 6 hours as needed for pain or fever. Children and babies can generally receive over-the-counter Motrin every 6 to 8 hours, as needed for pain or fever, but no more than 4 doses should be given in 24 hours. Motrin can be taken with food or milk to prevent stomach upset. If you are taking Motrin regularly, you should take it at the same time every day. Follow the directions on the package or prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Motrin exactly as directed. Do not take more or less or take it more often than directed on the package label or prescribed by your doctor.

Motrin comes alone and in combination with other medications. Some of these combination products are available only by prescription, and some of these combination products are available without a prescription and are used to treat symptoms of cough and cold and other conditions. If your doctor has prescribed a medication containing Motrin, you should be careful not to take any over-the-counter medication that also contains Motrin.

Swallow the tablet whole; do not chew or crush it.

If you select a product to treat cough or cold symptoms, ask your doctor or pharmacist about which product is best for you. Carefully check labels on non-prescription products before using two or more products at the same time. These products may contain the same active ingredients and taking them together could cause you to overdose. This is especially important if you are giving a child cough and cold medicine.

Over-the-counter combination cough and cold products, including products containing Motrin, can cause serious side effects or death in young children. Do not give these products to children under the age of 4. If you are giving these products to children ages 4 to 11, be careful and follow the directions on the package carefully.

If you are giving Motrin or a combination product containing Motrin to a child, carefully read the label on the package to make sure it is the right product for a child of that age. Do not give Motrin products made for adults to children.

Before giving an Motrin product to a child, check the package label to see how much medicine the child should receive. Give the dose that matches the child’s age in the table. Ask your child’s doctor if you don’t know how much medicine to give him.

Shake the suspension and drops well before each use to mix the medicine evenly. Use the supplied measuring cup to measure each dose of the suspension, and use the supplied dosing device to measure each dose of the drops.

Chewable tablets can cause burning in the mouth or throat. Take the chewable tablets with food or water.

Stop taking over-the-counter Motrin and call your doctor if your symptoms worsen, you develop new or unexpected symptoms, the part of your body that was painful becomes red or swollen, your pain lasts more than 10 days, or your fever lasts more than Three days. Stop giving Motrin without a prescription to your child and call your child’s doctor if your child does not start to feel better during the first 24 hours of treatment. Also stop giving your child over-the-counter Motrin and call your child’s doctor if he develops new symptoms, such as redness or swelling in the painful part of his body, or if your child’s pain or fever gets worse or lasts longer. 3 days.

Do not give over-the-counter Motrin to a child who has a sore throat that does not go away, or that occurs with fever, headache, nausea, or vomiting. Call your child’s doctor right away, as these symptoms may be signs of a more serious condition.

Other uses for this medicine
Motrin is also sometimes used to treat ankylosing spondylitis (arthritis that mainly affects the spine), gouty arthritis (joint pain caused by the accumulation of certain substances in the joints), and psoriatic arthritis (arthritis that occurs with long-lasting skin). disease causing flaking and swelling). Talk to your doctor about the risks of using this medication for your condition.

This medication is sometimes prescribed for other uses; Ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking Motrin,
Tell your doctor and pharmacist if you are allergic to Motrin, aspirin, or other NSAIDs, such as ketoprofen and naproxen (Aleve, Naprosyn), any other medications, or any of the ingredients inactive in the type of Motrin you plan to take. Ask your pharmacist or check the package label for a list of inactive ingredients.

  • Tell your doctor and pharmacist what prescription and over-the-counter medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: angiotensin-converting enzyme (ACE) inhibitors such as benazepril (Lotensin, in Lotrel), captopril, enalapril (Vasotec, in Vaseretic), fosinopril, lisinopril ( in Zestoretic), moexipril (Univasc), perindopril (Aceon, in Prestalia), quinapril (Accupril, in Quinaretic), ramipril (Altace) and trandolapril (Mavik, in Tarka); angiotensin receptor blockers such as candesartan (Atacand, in Atacand HCT), eprosartan (Teveten), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, in Benicar HCT, in Tribenzor) , telmisartan (Micardis, in Micardis HCT, in Twynsta) and valsartan (in Exforge HCT); beta-blockers such as atenolol (Tenormin, in Tenoretic), labetalol (Trandate), metoprolol (Lopressor, Toprol XL, in Dutoprol), nadolol (Corgard, in Corzide) and propranolol (Hemangeol, Inderal, Innopran); diuretics (‘water pills’); lithium (Lithobid); and methotrexate (Otrexup, Rasuvo, Trexall). Your doctor may need to change the doses of your medications or monitor you more closely for side effects.
  • Do not take over-the-counter Motrin with any other pain medication unless your doctor tells you to.
  • Tell your doctor if you have or have ever had any of the conditions mentioned in the IMPORTANT WARNING section or asthma, especially if you also have a stuffy or runny nose or nasal polyps (inflammation of the inside of the nose); heart failure; swelling of the hands, arms, feet, ankles, or lower legs; lupus (a condition in which the body attacks many of its own tissues and organs, often including the skin, joints, blood, and kidneys); or liver or kidney disease. If you are giving Motrin to a child, tell the child’s doctor if the child has not been drinking fluids or has lost a large amount of fluid due to repeated vomiting or diarrhea.
  • Tell your doctor if you are pregnant, especially if you are in the last months of your pregnancy; you plan to become pregnant; or you are breastfeeding. If you become pregnant while taking Motrin, call your doctor.
  • If you are going to have surgery, including dental surgery, tell the doctor or dentist that you are taking Motrin.
  • Talk to your doctor about the risks and benefits of taking Motrin if you are 75 years of age or older. Do not take this medication for a longer period of time or in a higher dose than recommended on the product label or by your doctor.
  • If you have phenylketonuria (PKU, a congenital disease in which mental retardation develops if a specific diet is not followed), read the package label carefully before taking Motrin without a prescription. Some types of over-the-counter Motrin can be sweetened with aspartame, a source of phenylalanine.

What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?
If you are taking Motrin regularly, take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Motrin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • constipation
  • dizziness
  • nervousness
  • diarrhea
  • gas or bloating
  • ringing in the ears

Some side effects can be serious. If you experience any of the following symptoms, or those mentioned in the IMPORTANT WARNING section, call your doctor immediately. Do not take any more Motrin until you speak to your doctor.

  • unexplained weight gain
  • shortness of breath or difficulty breathing
  • swelling of the abdomen, feet, ankles, or lower legs
  • swelling of the eyes, face, throat, arms, or hands
  • difficulty breathing or swallowing
  • hoarseness
  • fever
  • yellowing of the skin or eyes
  • flu-like symptoms
  • pale skin
  • fast heartbeat
  • blisters
  • rash
  • itching
  • hives
  • excessive tiredness
  • pain in the upper right part of the stomach
  • nausea
  • loss of appetite
  • cloudy, discolored, or bloody urine
  • back pain
  • stiff neck
  • headache
  • confusion
  • aggression
  • difficult or painful urination
  • blurred vision, changes in color vision, or other vision problems
  • red or painful eyes

Motrin can cause other side effects. Call your doctor if you have any unusual problems while taking this medicine.

If you experience a serious side effect, you or your doctor can submit a report online to the Food and Drug Administration (FDA) MedWatch Adverse Event Reporting Program ( or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?
Keep this medicine in its container, tightly closed and out of the reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medications out of the sight and reach of children, as many containers (such as those for taking pills weekly and those used for eye drops, creams, patches, and inhalers) are not resistant to children and children. young children can easily open them. To protect young children from poisoning, always close the safety caps and immediately put the medicine in a safe place, one that is up and away and out of your sight and reach.

Unnecessary medications must be disposed of in special ways to ensure that pets, children, and others cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to get rid of your medication is through a medication take-back program. Talk to your pharmacist or contact your local recycling / trash department to find out about return programs in your community. Consult the FDA’s Safe Drug Disposal website ( for more information if you do not have access to a take-back program.

In case of emergency/overdose
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim collapsed, had a seizure, is having trouble breathing, or cannot wake up, call 911 immediately.

Symptoms of overdosage may include:

  • dizziness
  • fast eye movements that you cannot control
  • blue color around the lips, mouth, and nose
  • slow breathing or short periods of time without breathing

What other information should I know?
If you are taking prescription Motrin, do not let anyone else take your medicine. Ask your pharmacist any questions you have about refilling your prescription.

It is important that you keep a written list of all prescription and over-the-counter (non-prescription) medications you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should carry this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to take with you in case of emergencies.

Brand names

  • Addaprin
  • Advil
  • Cedaprin
  • I-Prin
  • Midol
  • Motrin
  • Motrin IB
  • NeoProfen
  • Profen IB
  • Proprinal
  • Ultraprin

Brand names of combination products

  • Advil® PM (containing Diphenhydramine, Ibuprofen)
  • Combunox® (containing Ibuprofen, Oxycodone)
  • Duexis® (containing Famotidine, Ibuprofen)
  • Ibudone® (containing Hydrocodone, Ibuprofen)
  • Reprexain® (containing Hydrocodone, Ibuprofen)
  • Vicoprofen® (containing Hydrocodone, Ibuprofen)

Disclaimer: We have made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.

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