Lixisenatide Injection : Uses, Side Effects, Interactions & More

Why is this medication prescribed?
Lixisenatide Injection is used along with diet and exercise to treat type 2 diabetes (a condition in which the body does not normally use insulin and therefore cannot control the amount of sugar in the blood). Lixisenatide Injection is not used to treat type 1 diabetes (a condition in which the body does not make insulin and therefore cannot control the amount of sugar in the blood). Lixisenatide is not used in place of insulin to treat people with diabetes who need insulin. Lixisenatide Injection belongs to a class of medications called incretin mimetics. It works by stimulating the pancreas to secrete insulin when blood sugar levels are high. Insulin helps move sugar from the blood to other tissues in the body where it is used for energy. Lixisenatide Injection also slows the emptying of the stomach and causes a decreased appetite.

Over time, people who have diabetes and high blood sugar levels can develop serious or life-threatening complications, such as heart disease, stroke, kidney problems, nerve damage, and eye problems. Using medications, making lifestyle changes (for example, diet, exercise, quitting smoking), and checking your blood sugar regularly can help control your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other complications related to diabetes, such as kidney failure, nerve damage (numbness, cold legs or feet; decreased sexual ability in men and women), eye problems, including vision changes or loss, or gum disease. Your doctor and other health care providers will talk to you about the best way to control your diabetes.

Your doctor or pharmacist will provide you with the manufacturer’s patient information sheet (Medication Guide) when you begin treatment with Lixisenatide Injection and each time you get a refill. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) to obtain the Medication Guide.

How should this medicine be used?
Lixisenatide Injection is presented as a pre-filled dosing pen to be injected subcutaneously (under the skin). It is usually injected once a day, within one hour (60 minutes) before the first meal of the day. Use Lixisenatide Injection at around the same time every day. Follow the directions on your prescription label carefully and ask your doctor or pharmacist to explain any part you do not understand. Use Lixisenatide Injection exactly as directed. Do not use more or less or use it more often than prescribed by your doctor.

Your doctor will probably start with a low dose of lixisenatide and then increase it after 14 days.

Lixisenatide Injection controls diabetes but does not cure it. Continue to use Lixisenatide Injection even if you feel well. Do not stop using Lixisenatide Injection without talking to your doctor.

You will need to purchase needles separately. Ask your doctor or pharmacist what type of needles you will need to inject your medicine. Be sure to read and understand the manufacturer’s instructions for injecting lixisenatide. Also make sure you know how and when to set up a new pen. If you are blind or have vision problems, do not use this pen without assistance. Ask your doctor or pharmacist to show you how to use the pen. Follow the instructions carefully.

Always look at the lixisenatide solution before injecting it. It must be transparent, colorless and free of particles. Do not use lixisenatide if it is colored, cloudy, thick, or contains solid particles, or if the pen expiration date has passed.

Lixisenatide Injection can be given to the thigh (upper leg), abdomen (stomach area), or upper arm. Use a different site for each injection. Let the pen warm to room temperature before using if you store it in the refrigerator.

Never reuse needles and never share needles or pens. Always remove the needle just after the dose is injected. Throw the needles in a puncture-resistant container. Ask your doctor or pharmacist how to dispose of the puncture-resistant container.

Other uses for this medicine
This medication may be prescribed for other uses; Ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking Lixisenatide Injection,

  • Tell your doctor and pharmacist if you are allergic to lixisenatide, exenatide (Bydureon, Byetta), liraglutide (Saxenda, Victoza), any other medications, or any of the ingredients in Lixisenatide Injection. Consult your pharmacist or consult the Medication Guide for a list of ingredients.
  • Tell your doctor and pharmacist what prescription and over-the-counter medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. It is especially important to tell your doctor about all the medicines you take by mouth because lixisenatide can change the way your body absorbs these medicines. If you are taking pain medications, such as acetaminophen (Tylenol) or antibiotics, take them at least one hour before lixisenatide injection. If you are taking oral contraceptives (birth control pills) take them at least 1 hour before or 11 hours after using lixisenatide injection. Also, be sure to mention any of the following medications: Chlorpropamide (Diabinese), Digoxin (Lanoxin), Glimepiride (Amaryl, in Duetact), Glipizide (Glucotrol), Glyburide (DiaBeta, Glynase, in Glucovance), Insulin, Tolazamide, and Tolbutamide. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • Tell your doctor if you drink or have ever drunk large amounts of alcohol, or if you have or have ever had serious stomach problems, including gastroparesis (slow movement of food from the stomach to the small intestine) or trouble digesting foods; pancreatitis (swelling of the pancreas); gallstones (solid deposits that form in the gallbladder); or kidney disease.
  • Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking lixisenatide injection, call your doctor.
  • Ask your doctor what to do if there is a big change in your diet, exercise, or weight; or if you get sick, develop an infection or fever, experience unusual stress, or get injured. These changes and conditions can affect your blood sugar level and the amount of lixisenatide injection you may need.

What special dietary instructions should I follow?
Be sure to follow all exercise and dietary recommendations made by your doctor or dietitian. It is important to eat a healthy diet.

What should I do if I forget a dose?
Inject the missed dose within 1 hour (60 minutes) before your next meal. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not inject a double dose to make up for a missed one.

What side effects can this medication cause?
This medicine may cause changes in your blood sugar level. You should know the symptoms of low and high blood sugar levels and what to do if you have these symptoms.

Lixisenatide injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea
  • vomiting
  • diarrhea
  • constipation
  • indigestion
  • bloating
  • headache
  • pain, itching, or redness at the injection site

Some side effects can be serious. If you experience any of these symptoms, stop taking lixisenatide injection and call your doctor immediately or get emergency medical treatment:

  • ongoing pain that begins in the upper left or middle of the stomach but may spread to the back, with or without vomiting
  • hives
  • rash
  • itching
  • pounding heartbeat
  • fainting or feeling dizzy
  • swelling of the eyes, face, mouth, tongue, throat, feet, ankles, or lower legs
  • difficulty swallowing or breathing
  • hoarseness
  • decreased urination,
  • very dry mouth or skin or extreme thirst

Lixisenatide Injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medicine.

If you experience a serious side effect, you or your doctor can submit an online report to the Food and Drug Administration (FDA) MedWatch Adverse Event Reporting Program (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?
Keep this medicine in its container, tightly closed and out of the reach of children. Store it away from light, heat, dust and dirt. Store unused lixisenatide pens in the refrigerator (2 ° C to 8 ° C] 36 ° F to 46 ° F). Once you are using a lixisenatide pen, store it at room temperature (below 86 ° F [30 ° C] ) with its cap on. Do not freeze. Do not use lixisenatide if it has been frozen. Dispose of lixisenatide pens in a puncture-resistant container after 14 days from their first use, even if some solution remains in the pen.

When traveling, be sure to keep lixisenatide pencils dry. Unused pens must be refrigerated or kept at a cold temperature between 36 ° F and 46 ° F (2 ° C to 8 ° C). Pens in use can be stored at room temperature up to 86 ° F [30 ° C] (not in a car glove box or other hot place).

Unnecessary medications must be disposed of in a special way to ensure that pets, children and others cannot consume them. However, you should not flush this medicine down the toilet. Instead, the best way to get rid of your medication is through a medication take-back program. Talk to your pharmacist or contact your local garbage / recycling department for information on return programs in your community. Consult the FDA’s Safe Drug Disposal website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medications out of the sight and reach of children, as many containers (such as those for taking pills weekly and those used for eye drops, creams, patches, and inhalers) are not resistant to children and children. young children can easily open them. To protect young children from poisoning, always close the safety caps and immediately put the medicine in a safe place, one that is up and away and out of your sight and reach. http://www.upandaway.org

In case of emergency/overdose
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim collapsed, had a seizure, is having trouble breathing, or cannot wake up, call 911 immediately.

Symptoms of overdose may include the following:

  • nausea
  • vomiting
  • diarrhea
  • abdominal pain or bloating
  • indigestion
  • constipation

What other information should I know?
Keep all appointments with your doctor and the laboratory. Your blood sugar and glycated hemoglobin (HbA1c) should be checked regularly to determine your response to lixisenatide injection. Your doctor will tell you how to check your response to this medicine by measuring your blood or urine sugar levels at home. Follow these instructions carefully.

Do not let anyone else take your medicine. Ask your pharmacist any questions you have about refilling your prescription.

It is important that you keep a written list of all prescription and over-the-counter (non-prescription) medications you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should carry this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in emergencies.

Brand Names

  • Adlyxin
  • Soliqua (as a combination product containing Insulin Glargine and Lixisenatide)

Disclaimer: We have made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.

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