Humalog Mix75/25 : Uses, Side Effects, Interactions & More

Why is this medication prescribed?
Humalog Mix75/25 (Insulin Lispro) is used to treat type 1 diabetes (a condition in which the body does not make insulin and therefore cannot control the amount of sugar in the blood). It is also used to treat people with type 2 diabetes (a condition in which the body does not normally use insulin and therefore cannot control the amount of sugar in the blood) who need insulin to control their diabetes. In patients with type 1 diabetes, Humalog Mix75/25 is always used with another type of insulin, unless it is used in an external insulin pump. In patients with type 2 diabetes, Humalog Mix75/25 can be used with another type of insulin or with oral diabetes medications. Humalog Mix75/25 is a short-acting artificial version of human insulin. Humalog Mix75/25 works by replacing the insulin normally produced by the body and helping to move sugar from the blood to other tissues in the body where it is used for energy. It also prevents the liver from making more sugar.

Over time, people who have diabetes and high blood sugar levels can develop serious or life-threatening complications, such as heart disease, stroke, kidney problems, nerve damage, and eye problems. Using medications, making lifestyle changes (for example, diet, exercise, quitting smoking), and checking your blood sugar regularly can help control your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other complications related to diabetes, such as kidney failure, nerve damage (numbness, cold legs or feet; decreased sexual ability in men and women), eye problems, including vision loss or changes or gum disease. Your doctor and other health care providers will talk to you about the best way to control your diabetes.

How should this medicine be used?
Humalog Mix75/25 (Insulin Lispro) comes as a solution (liquid) and a suspension (liquid with particles that will settle at rest) to be injected subcutaneously (under the skin). Humalog Mix75/25 solution (Admelog, Humalog) is usually injected within 15 minutes before a meal or immediately after a meal. The Humalog Mix75/25 suspension (Humalog Mix 75/25 or Humalog Mix 50/50) should be injected 15 minutes before a meal. Your doctor will tell you how many times you should inject Humalog Mix75/25 each day. Follow the directions on your prescription label carefully and ask your doctor or pharmacist to explain any part you do not understand. Use Humalog Mix75/25 exactly as directed. Do not use more or less or use it more often than prescribed by your doctor.

Humalog Mix75/25 solution can also be injected intravenously (into a vein) by a doctor or nurse in a healthcare setting. A doctor or nurse will monitor you carefully for side effects.

Never use Humalog Mix75/25 when you have symptoms of hypoglycemia (low blood sugar) or if you have checked your blood sugar level and found it low. Do not inject insulin into an area of ​​the skin that is red, swollen, itchy, or thickened.

Humalog Mix75/25 controls diabetes but does not cure it. Continue to use Humalog Mix75/25 even if you feel well. Do not stop using Humalog Mix75/25 without talking to your doctor. Do not change to another brand or type of insulin or change the dose of any type of insulin you are using without talking to your doctor. Always check the insulin label to make sure you have received the correct type of insulin from the pharmacy.

Humalog Mix75/25 comes in vials, cartridges containing medications, and should be placed in dispenser pens and dispenser pens containing medication cartridges. Make sure you know what type of container your Humalog Mix75/25 comes in and what other supplies, such as needles, syringes, or pens, you will need to inject your medication.

If your Humalog Mix75/25 comes in vials, you will need to use syringes to inject your dose. Ask your doctor or pharmacist to show you how to inject Humalog Mix75/25 with a syringe. Ask your doctor or pharmacist if you have questions about the type of syringe to use.

If your Humalog Mix75/25 comes in cartridges, you will need to purchase a separate insulin pen. Check the manufacturer’s information for the patient to see which pen type is appropriate for the size of the cartridge you are using. Carefully read the instructions that come with your pen and ask your doctor or pharmacist to show you how to use it. Ask your doctor or pharmacist if you have questions about the type of pen you should use.

If your Humalog Mix75/25 comes in pens, be sure to read and understand the manufacturer’s instructions. Ask your doctor or pharmacist to show you how to use the pen. Follow the instructions carefully and always print the pen before use.

Never reuse needles or syringes and never share needles, syringes, cartridges, or pens. If you are using an insulin pen, always remove the needle just after the dose is injected. Dispose of needles and syringes in a puncture-resistant container. Ask your doctor or pharmacist how to dispose of the puncture-resistant container.

Your doctor may tell you to mix your Humalog Mix75/25 solution with another type of insulin (NPH insulin) in the same syringe. Your doctor will tell you exactly how to do this. Always put Humalog Mix75/25 into the syringe first, always use the same brand of syringe, and inject insulin immediately after mixing. Humalog Mix75/25 solution should not be mixed with insulin preparations other than NPH insulin. The Humalog Mix75/25 suspension should not be mixed with any other insulin preparation.

Your doctor may direct you to dilute Humalog Mix75/25 prior to injection to allow easier measurement of your dose. Your doctor will tell you exactly how to do it.

Humalog Mix75/25 can be injected into the thighs, stomach, upper arms, or buttocks. Each time Humalog Mix75/25 is injected, you must choose a location that is at least 1/2 inch (1.25 centimeters) from where you last administered the injection.

Always look at your Humalog Mix75/25 before injecting it. If you are using the Humalog Mix75/25 solution, the insulin should be clear and colorless. Do not use this type of Humalog Mix75/25 if it is colored, cloudy, or contains solid particles. If you are using the Humalog Mix75/25 suspension, the insulin should appear cloudy or milky after mixing. Do not use this type of insulin if there are lumps in the liquid or if there are solid white particles sticking to the bottom or the walls of the bottle. Do not use any type of insulin after the expiration date printed on the bottle has passed.

Humalog Mix75/25 suspension should be gently shaken or rolled between hands to mix before use. Ask your doctor or pharmacist if the type of insulin you are using should be mixed and how you should mix it if necessary.

Humalog Mix75/25 in vials or cartridges can also be used with an external insulin pump. Before using Humalog Mix75/25 in a pump system, read the label on the pump to ensure that the pump can be used for continuous delivery of rapid-acting insulin. Read the pump manual for recommended reservoir and tube sets, and ask your doctor or pharmacist to show you how to use the insulin pump. Do not dilute Humalog Mix75/25 or mix it with any other type of insulin when using it with an external insulin pump. When using Humalog Mix75/25 with an external insulin pump, replace the insulin in the reservoir at least every 7 days and change the infusion set and infusion set insertion site at least every 3 days. tell your doctor and use a different infusion site.

Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before using Humalog Mix75/25,

  • Tell your doctor and pharmacist if you are allergic to insulin (Humulin, Novolin, others), any of the ingredients in Humalog Mix75/25, or any other medications. Ask your pharmacist or check the manufacturer’s patient information for a list of ingredients.
  • Tell your doctor and pharmacist what prescription and over-the-counter medications, vitamins, nutritional supplements, and herbal products you are taking. Be sure to mention any of the following: angiotensin converting enzyme (ACE) inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc) , perindopril, (Aceon), quinapril (Accupril), ramipril (Altace) and trandolapril (Mavik); angiotensin receptor blockers such as azilsartan (Edarbi), candesartan (Atacand, in Atacand HCT), eprosartan (Teveten, in Teveten HCT), irbesartan (Avapro, in Avalide), losartan (Cozaar, in Hyzaar), olmesartan (Benicar, in Azor, Benicar HCT), telmisartan (Micardis, in Micardis HCT) and valsartan (Diovan, in Diovan HCT, Exforge); beta-blockers such as atenolol (Tenormin), labetalol (Normodyne), metoprolol (Lopressor, Toprol XL), nadolol (Corgard) and propranolol (Inderal); certain cholesterol-lowering medications, such as fenofibrate (Antara, Lofibra, TriCor, Triglide), gemfibrozil (Lopid), and niacin (Niacor, Niaspan, in Advicor); certain medicines for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) including atazanavir (Reyataz), darunavir (Prezista), fosamprenavir (Lexiva), indinavir (Crixivan), lopinavir (Kaletra), nelfinavir (Viracept) , ritonavir (Norvir), saquinavir (Invirase) and tipranavir (Aptivus); clonidine (Catapres, in Clorpres), danazol, digoxin (Digitek, Lanoxin); disopyramide (Norpace); diuretics (‘water pills’); fluoxetine (Prozac, Serafem, in Symbyax); Hormone replacement therapy; isoniazid (INH, Nydrazid); lithium (Eskalith, Lithobid); asthma and cold medications; medications for mental illness and nausea; monoamine oxidase inhibitors including isocarboxazide (Marplan), phenelzine (Nardil), selegiline (Eldepryl), and tranylcypromine (Parnate); octreotide (Sandostatin); oral contraceptives (birth control pills); oral diabetes medications such as pioglitazone (Actos, in Actoplus Met et al.) and rosiglitazone (Avandia, in Avandamet et al.); oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone); patiromer (Veltassa); pentamidine (NebuPent, Pentam); pentoxifylline (Trental); pramlintida (Symlin); reserpine painkillers salicylates such as aspirin, magnesium choline trisalicylate (Trisalate), choline salicylate (Arthropan), diflunisal (Dolobid), magnesium salicylate (Doan’s, others), and salsalate (Argesic, Disalcid, Salgesic) ; sodium polystyrene sulfonate (Kalexate, Kionex, SPS); somatropin (Nutropin, Serostim, others); sulfa antibiotics; and thyroid medications. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
  • Tell your doctor if you have or have ever had nerve damage caused by your diabetes; heart failure; or if you have any other medical conditions, such as heart, liver, or kidney disease. Also tell your doctor if you have frequent episodes of hypoglycemia.
  • Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while using Humalog Mix75/25, call your doctor.
  • If you are going to have surgery, including dental surgery, tell the doctor or dentist that you are using Humalog Mix75/25.
  • Alcohol can cause a change in blood sugar. Ask your doctor about the safe use of alcoholic beverages and prescription or over-the-counter medications that contain alcohol while you are using Humalog Mix75/25.
  • Ask your doctor what to do if you become ill, experience unusual stress, or change your diet, exercise, or activity program. These changes can affect your dosing schedule and the amount of insulin you will need.
  • You should know when you start using Humalog Mix75/25 or if you have a large dose increase, you may experience blurred vision or other vision problems, or a painful, burning, weak, or numb sensation in your hands, arms, feet, or legs. These side effects should go away, but tell your doctor if these effects continue.
  • Ask your doctor how often you should check your blood sugar level. Be aware that hypoglycemia can affect your ability to perform tasks such as driving, and ask your doctor if you need to check your blood sugar level before driving or operating machinery.
  • High blood sugar can happen quickly if an insulin pump or infusion set stops working properly or if the insulin in the pump reservoir becomes inactive (degraded). If the problem cannot be found and corrected quickly, call your doctor. Temporary use of insulin by subcutaneous injection (with syringes or an insulin pen) may be necessary. Make sure you have your backup insulin and supplies on hand, and ask your doctor or pharmacist to show you how to use them.

What special dietary instructions should I follow?
Be sure to follow all dietary recommendations made by your doctor or dietitian. It is important to eat a healthy diet and eat approximately the same amounts of the same types of food at approximately the same time each day. Skipping or delaying meals or changing the amount or type of food you eat can cause problems with blood sugar control.

What should I do if I forget a dose?
Humalog Mix75/25 should be injected shortly before or after a meal. If you remember your dose before or shortly after your meal, inject the missed dose right away. If some time has passed since your meal, follow the instructions provided by your doctor or call your doctor to find out if you should inject the missed dose. Do not inject a double dose to make up for a missed one.

What side effects can this medication cause?

This medication may cause changes in your blood sugar. You should know the symptoms of low and high blood sugar and what to do if you have these symptoms.

Humalog Mix75/25 may cause side effects. Tell your doctor if the following symptoms are severe or do not go away:

  • redness, swelling, or itching in the place where you injected Humalog Mix75/25
  • changes in the feel of your skin such as skin thickening or a little indentation in the skin
  • weight gain
  • constipation

Some side effects can be serious. The following symptoms are uncommon, but if you experience any of them, call your doctor immediately:

  • rash and itching, difficulty breathing, hives, wheezing, fast heartbeat, sweating,, and feeling drowsy, dizzy or confused
  • weakness, muscle cramps, abnormal heartbeat
  • shortness of breath
  • large weight gain in a short period of time
  • swelling of the arms, hands, feet, ankles, or lower legs

Humalog Mix75/25 may cause other side effects. Call your doctor if you have any unusual problems while using this medicine.

If you experience a serious side effect, you or your doctor can submit an online report to the Food and Drug Administration (FDA) MedWatch Adverse Event Reporting Program ( or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?
Keep this medicine in the container it entered and out of the reach of children. Store Humalog Mix75/25 suspension and solution vials in the refrigerator, but do not freeze them. You can store the vial of solution or suspension you are using outside the refrigerator at room temperature, away from heat or direct light, for up to 28 days. If your doctor tells you to dilute your Humalog Mix75/25 solution, you can keep one vial of diluted Humalog for 28 days in the refrigerator or 14 days at room temperature, and one vial of Admelog diluted for 1 day (24 hours) in the refrigerator, or 4 hours at room temperature. Store Humalog Mix75/25 solution or suspension pens and cartridges that are not in use in the refrigerator but do not freeze them. Store the Humalog Mix75/25 solution or pen and suspension cartridge you are using out of the refrigerator at room temperature and away from heat or direct light. Humalog Mix75/25 solution pens and cartridges used and stored outside the refrigerator should be discarded after 28 days, and Humalog Mix75/25 suspension pens stored outside the refrigerator should be discarded after 10 days. Humalog Mix75/25 solutions used in an external insulin pump should be discarded if exposed to temperatures above 98.6 ° F. Insulin temperature may be higher than outside air temperature if the pump casing, cover, The tube or sports case is exposed to sunlight or direct heat.

It is important to keep all medications out of the sight and reach of children, as many containers (such as those for taking pills weekly and those used for eye drops, creams, patches, and inhalers) are not resistant to children and children. young children can easily open them. To protect young children from poisoning, always close the safety caps and immediately put the medicine in a safe place, one that is up and away and out of your sight and reach.

Unnecessary medications must be disposed of in special ways to ensure that pets, children, and others cannot consume them. However, you should not flush this medicine down the toilet. Instead, the best way to get rid of your medication is through a medication take-back program. Talk to your pharmacist or contact your local recycling / garbage department to find out about return programs in your community. Consult the FDA’s Safe Drug Disposal website ( for more information if you do not have access to a take-back program.

In case of emergency/overdose
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim collapsed, had a seizure, is having trouble breathing, or cannot wake up, call 911 immediately.

Humalog Mix75/25 overdose can occur if you use too much Humalog Mix75/25 or if you use the right amount of Humalog Mix75/25 but eat less than usual or exercise more than usual. Humalog Mix75/25 overdose can cause hypoglycemia. If you have any symptoms of hypoglycemia, follow your doctor’s instructions for what you should do if you develop hypoglycemia. Other symptoms of overdose:

  • coma
  • seizures

What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain laboratory tests to check your body’s response to Humalog Mix75/25. Your doctor will also tell you how to check your Humalog Mix75/25 response by measuring your blood sugar levels at home. Follow these instructions carefully.

You should always wear a diabetic ID bracelet to make sure you get proper treatment in an emergency.

Do not allow anyone to use your medicine. Ask your pharmacist any questions you have about refilling your prescription.

It is important to keep a written list of all prescription and over-the-counter (non-prescription) medications you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should carry this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in emergencies.

Brand Names

  • Admelog
  • Humalog
  • Humalog Mix50/50
  • Humalog Mix75/25

Disclaimer: We have made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.

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