Anthrax Vaccine : Uses, Side Effects, Interactions & More
What is anthrax?
Anthrax is a serious disease that can affect both animals and humans. It is caused by a bacteria called Bacillus anthracis. People can get anthrax from contact with infected animals, wool, meat, or hides.
Cutaneous Anthrax. In its most common form, anthrax is a skin disease that causes skin ulcers and usually fever and fatigue. Up to 20% of these cases are fatal if left untreated.
Gastrointestinal Anthrax. This form of anthrax can result from eating raw or undercooked infected meat. Symptoms may include fever, nausea, vomiting, sore throat, abdominal pain and swelling, and swollen lymph nodes. Gastrointestinal anthrax can cause blood poisoning, shock, and death.
Inhalation Anthrax. This form of anthrax occurs when B. anthracis is inhaled and is very serious. The first symptoms may include a sore throat, mild fever, and muscle aches. After several days, these symptoms are followed by severe breathing problems, shock, and often meningitis (inflammation of the lining of the brain and spinal cord). This form of anthrax requires hospitalization and aggressive treatment with antibiotics. It is often fatal.
What is anthrax vaccine?
The anthrax vaccine protects against the disease of anthrax. The vaccine used in the United States does not contain B. anthracis cells and does not cause anthrax. The anthrax vaccine was licensed in 1970 and reauthorized in 2008.
Based on limited but strong evidence, the vaccine protects against cutaneous (skin) and inhalation anthrax.
Who should get anthrax vaccine and when?
Anthrax vaccine is recommended for certain people 18 through 65 years of age who might be exposed to large amounts of bacteria on the job, including:
- certain laboratory or remediation workers
- some people handling animals or animal products
- some military personnel, as determined by the Department of Defense
These people should receive five doses of vaccine (in the muscle): the first dose when the risk of possible exposure is identified, and the remaining doses at 4 weeks and 6, 12 and 18 months after the first dose.
Annual booster doses are needed for continued protection.
If a dose is not given at the scheduled time, it is not necessary to start the series again. Resume the series as soon as possible.
The anthrax vaccine is also recommended for unvaccinated people who have been exposed to anthrax in certain situations. These people should receive three doses of vaccine (under the skin), with the first dose as soon as possible after exposure, and the second and third doses given 2 and 4 weeks after the first.
Who should not get anthrax vaccine or should wait?
- Anyone who has had a severe allergic reaction to a previous dose of anthrax vaccine should not receive another dose.
- Anyone who has a severe allergy to any component of the vaccine should not receive a dose. Tell your provider if you have any serious allergies, including latex.
- If you have ever had Guillain Barr syndrome (GBS), your provider may recommend against getting the anthrax vaccine.
- If you have a moderate or severe illness, your provider may ask you to wait until you recover to get the vaccine. People with mild illnesses can usually get vaccinated.
- Vaccination may be recommended for pregnant women who have been exposed to anthrax and are at risk of developing inhalation illness. Nursing mothers can safely get the anthrax vaccine.
What are the risks from anthrax vaccine?
Like any medicine, a vaccine can cause a serious problem, such as a severe allergic reaction.
Anthrax is a very serious disease and the risk of serious harm from the vaccine is extremely small.
- Tenderness on the arm where the shot was given (about 1 person out of 2)
- Redness on the arm where the shot was given (about 1 out of 7 men and 1 out of 3 women)
- Itching on the arm where the shot was given (about 1 out of 50 men and 1 out of 20 women)
- Lump on the arm where the shot was given (about 1 out of 60 men and 1 out of 16 women)
- Bruise on the arm where the shot was given (about 1 out of 25 men and 1 out of 22 women)
- Muscle aches or temporary limitation of arm movement (about 1 out of 14 men and 1 out of 10 women)
- Headaches (about 1 out of 25 men and 1 out of 12 women)
- Fatigue (about 1 out of 15 men, about 1 out of 8 women)
- Serious allergic reaction (very rare – less than once in 100,000 doses).
As with any vaccine, other serious problems have been reported. But these do not appear to occur more often among anthrax vaccine recipients than among unvaccinated people.
There is no evidence that the anthrax vaccine causes long-term health problems.
Independent civilian committees have not found the anthrax vaccine to be a factor in unexplained illnesses among Gulf War veterans.
What if there is a moderate or severe reaction?
- Any unusual condition, such as a severe allergic reaction or high fever. If a severe allergic reaction occurs, it will be between a few minutes and an hour after the injection. Signs of a severe allergic reaction may include shortness of breath, weakness, hoarseness or wheezing, fast heartbeat, hives, dizziness, paleness, or swelling of the throat.
- Call a doctor or get the person to a doctor right away.
- Tell your doctor what happened, the date and time it happened, and when the vaccine was given.
- Ask your provider to report the reaction by submitting a Vaccine Adverse Event Reporting System (VAERS) form. Or you can file this report through the VAERS website at http://vaers.hhs.gov/index or by calling 1-800-822-7967. VAERS does not provide medical advice.
A federal program, the Countermeasures Injury Compensation Program, has been created under the PREP Act to help pay for medical care and other specific expenses for certain people who have a severe reaction to this vaccine.
If you have a reaction to the vaccine, your ability to sue may be limited by law. For more information, visit the program’s website at www.hrsa.gov/countermeasurescomp, or call 1-888-275-4772.
How can I learn more?
- Ask your doctor or other health care provider. They can give you the vaccine package insert or suggest other sources of information.
- Contact the Centers for Disease Control and Prevention (CDC): call 1-800-232-4636 (1-800-CDC-INFO) or visit the CDC’s website at http://emergency.cdc.gov/agent/anthrax/vaccination/.
- Contact the U.S Department of Defense (DoD): call 1-877-438-8222 or visit the DoD website at http://www.anthrax.osd.mil.
Anthrax Vaccine Information Statement. U.S. Department of Health and Human Services/Centers for Disease Control and Prevention National Immunization Program. 3/10/2010.
Disclaimer: We have made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.