Amphotec : Uses, Side Effects, Interactions & More

Why is this medication prescribed?

Amphotec (Amphotericin B lipid complex) injection is used to treat serious, possibly life-threatening fungal infections in people who have not responded to or cannot tolerate conventional amphotericin B therapy. Amphotec injection belongs to a class of medications called antifungals. It works by slowing the growth of fungi that cause infections.

How should this medicine be used?

Amphotec (Amphotericin B lipid complex) injection comes as a suspension (liquid) to be injected intravenously (into a vein). It is usually infused (slowly injected) intravenously once a day. The length of your treatment depends on your general health, how you tolerate the medicine, and the type of infection you have.

You may experience a reaction while receiving a dose of Amphotec Injection, which usually occurs 1 to 2 hours after the infusion begins. These reactions are usually more common and more severe with the first few doses of Amphotec. Your healthcare provider may prescribe other medications to lessen these side effects. Tell your doctor immediately if you experience any of these symptoms while receiving Amphotec injection: fever, chills, nausea, vomiting, shortness of breath, breathing problems, chest pain, dizziness, loss of consciousness, or fasting. , irregularity or pounding of the heart.

You can receive Amphotec injection in a hospital or you can use the medicine at home. If you are going to use an injection of Amphotec at home, your healthcare provider will show you how to infuse the medicine. Make sure you understand these instructions and consult your healthcare provider if you have any questions. Ask your healthcare provider what to do if you have a problem infusing Amphotec Injection.


If your symptoms do not improve or get worse while receiving Amphotec, tell your doctor. If you still have symptoms of infection after you finish your Amphotec injection, tell your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before receiving Amphotec injection,

  • Tell your doctor and pharmacist if you are allergic to Amphotec, any other medications, or any of the ingredients in Amphotec Injection. Ask your pharmacist for a list of the ingredients.
  • Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: aminoglycoside antibiotics such as amikacin, gentamicin, or tobramycin (Bethkis, Kitabis Pak, Tobi); antifungals such as clotrimazole, fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole (Extina, Nizoral, Xolegel) and miconazole (Oravig, Monistat); drugs for the treatment of cancer; corticotropin (H.P. Acthar Gel); cyclosporine (Gengraf, Neoral, Sandimmune); digoxin (Lanoxin); flucytosine (Ancobon); pentamidine (Nebupent, Pentam); oral steroids such as dexamethasone, methylprednisolone (Medrol), and prednisone (Rayos); and zidovudine (Retrovir, in Combivir, in Trizivir). Your doctor may need to change the doses of your medications or monitor you closely for side effects.
  • Tell your doctor if you are receiving leukocyte (white blood cell) transfusions.
  • Tell your doctor if you have or have ever had kidney disease.
  • Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while receiving Amphotec injection, call your doctor. Do not breastfeed while receiving the Amphotec injection.
  • If you are having surgery, including dental surgery, tell the doctor or dentist that you are receiving an injection of Amphotec.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What side effects can this medication cause?

Amphotec injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • stomach pain or cramping
  • heartburn
  • diarrhea
  • weight loss
  • loss of appetite
  • muscle or joint pain
  • injection site redness or swelling
  • pale skin
  • shortness of breath
  • dizziness
  • headache
  • coldness in the hands and feet

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

  • rash
  • skin blisters
  • wheezing
  • difficulty breathing
  • itching
  • swelling of the face, throat, tongue, lips, eyes
  • bloody vomit
  • black and tarry stools
  • blood in stool
  • yellowing of the skin or eyes
  • decreased urination

Amphotec injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medicine.

If you experience a serious side effect, you or your doctor can submit a report online to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain laboratory tests during your treatment to check your body’s response to injection of Amphotec.

Don’t let anyone else use your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important that you keep a written list of all prescription and over-the-counter (over-the-counter) medications you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you every time you visit a doctor or if you are admitted to a hospital. It is also important information to take with you in case of emergencies.

Brand Names

Disclaimer: We have made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.

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