Amikacin Injection : Uses, Side Effects, Interactions & More

IMPORTANT WARNING:

Amikacin can cause serious kidney problems. Kidney problems can occur more often in older people or in dehydrated people. Tell your doctor if you have or have ever had kidney disease. If you experience any of the following symptoms, call your doctor immediately: decreased urination; swelling of the face, arms, hands, feet, ankles, or lower legs; or unusual tiredness or weakness.

Amikacin can cause serious hearing problems. Hearing problems can occur more often in older people or in dehydrated people. Hearing loss can be permanent in some cases. Tell your doctor if you have or have ever had dizziness, vertigo, hearing loss, or ringing in the ears. If you experience any of the following symptoms, call your doctor immediately: hearing loss, roaring or ringing in the ears, or dizziness.

Amikacin can cause nerve problems. Tell your doctor if you have or have ever had burning, tingling, or numbness in your hands, arms, feet, or legs; muscle spasms or weakness; or seizures.

The risk that you will develop serious kidney, hearing, or other problems is higher if you are taking certain medications. Tell your doctor and pharmacist if you are taking acyclovir (Zovirax, Sitavig); amphotericin (Abelcet, Ambisome, Amphotec); bacitracin; capreomycin (Capastat); certain cephalosporin antibiotics such as cefazolin (Ancef, Kefzol), cefixime (Suprax), or cephalexin (Keflex); cisplatin; colistin (Coly-Mycin S); cyclosporine (Gengraf, Neoral, Restasis, Sandimmune); diuretics (‘water pills’) such as bumetanide, ethacrynic acid (Edecrin), furosemide (Lasix), or torsemide (Demadex); other aminoglycoside antibiotics such as gentamicin, kanamycin, neomycin (Neo-Fradin), paromomycin, streptomycin, or tobramycin; polymyxin B; or vancomycin (Vanocin). Your doctor may not want you to receive amikacin injection.

If you are having surgery, including dental surgery, tell the doctor or dentist that you are using amikacin injection.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain tests, including hearing tests, before and during treatment to check your body’s response to amikacin.

Why is this medication prescribed?

Amikacin injection is used to treat certain serious infections caused by bacteria such as meningitis (infection of the membranes that surround the brain and spinal cord) and infections of the blood, abdomen (stomach area), lungs, skin, bones, joints, and urinary tract. Amikacin injection is in a class of medications called aminoglycoside antibiotics. It works by killing bacteria.

Antibiotics, such as amikacin injection, do not work for colds, flu, or other viral infections. Taking antibiotics when they are not needed increases the risk of getting an infection later that resists antibiotic treatment.

How should this medicine be used?

Amikacin injection comes as a liquid that is injected intravenously (into a vein) or intramuscularly (into a muscle) every 8 to 12 hours (two to three times a day). When amikacin is injected intravenously, it is usually infused (injected slowly) over a period of 30 to 60 minutes. The length of your treatment depends on the type of infection you have.

You can receive the amikacin injection in a hospital or you can give the medicine at home. If you will be receiving amikacin injection at home, your healthcare provider will show you how to use the medicine. Make sure you understand these instructions and consult your healthcare provider if you have any questions.

You should begin to feel better during the first few days of treatment with amikacin injection. If your symptoms don’t improve or get worse, call your doctor.

Use amikacin injection until the prescription is finished, even if you feel better. If you stop using amikacin injection too soon or miss doses, your infection may not be fully treated and the bacteria may become resistant to antibiotics.

Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.

Other uses for this medicine

Amikacin is also sometimes used with other medications to treat tuberculosis (TB; a serious infection that affects the lungs and sometimes other parts of the body). Talk to your doctor about the risks of using this drug for your condition.

This medicine may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before receiving amikacin injection,

  • Tell your doctor and pharmacist if you are allergic to amikacin injection; other aminoglycoside antibiotics such as gentamicin, kanamycin, neomycin, streptomycin, or tobramycin; sulfites; any other medication; or any of the ingredients in amikacin injection. Ask your pharmacist for a list of the ingredients.
  • Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: other antibiotics such as amoxicillin (Amoxil, Larotid, Moxatag, in Augmentin, in Prevpac), ampicillin, or penicillin; dimenhydrinate (Dramamine); meclizine (Bonine); or non-steroidal anti-inflammatory drugs such as indomethacin (Indocin, Tivorbex). Your doctor may need to change the doses of your medications or monitor you closely for side effects. Many other medications can also interact with amikacin, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
  • Tell your doctor if you have or have had or have ever had cystic fibrosis (an inherited condition that affects the lungs and digestive system), problems with your muscles such as myasthenia gravis, or Parkinson’s disease.
  • Tell your doctor if you are pregnant or plan to become pregnant or breastfeed. If you become pregnant while using amikacin injection, call your doctor immediately. Amikacin can harm the fetus.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What side effects can this medication cause?

Amikacin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea
  • vomiting
  • diarrhea
  • headache
  • fever

Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical treatment:

  • rash
  • peeling or blistering of the skin
  • itching
  • hives
  • swelling of the eyes, face, throat, tongue, or lips
  • difficulty breathing or swallowing
  • hoarseness
  • severe diarrhea (watery or bloody stools) that may occur with or without fever and stomach cramps (may occur up to 2 months or more after your treatment)

Amikacin can cause other side effects. Call your doctor if you have any unusual problems while taking this medicine.

If you experience a serious side effect, you or your doctor can submit a report online to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

In case of emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim collapsed, had a seizure, is having trouble breathing, or is unable to wake up, immediately call 911 for emergency services.

What other information should I know?

It is important that you keep a written list of all prescription and over-the-counter (over-the-counter) medications you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should take this list with you each time you visit a doctor or if you go into hospital. It is also important information to take with you in case of emergencies.

Brand Names

  • Amikin®

Disclaimer: We have made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.

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