Alogliptin : Uses, Side Effects, Interactions & More

Why is this medication prescribed?

Alogliptin is used together with diet and exercise to lower blood sugar levels in patients with type 2 diabetes (a condition in which the blood sugar is too high because the body does not produce or use insulin normally). Alogliptin is in a class of medications called dipeptidyl peptidase-4 (DPP-4) inhibitors. It works by increasing the amount of insulin in the body to control blood sugar. Alogliptin is not used to treat type 1 diabetes (a condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that can develop if not high blood sugar levels are treated). ).

Over time, people with diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medicine, making lifestyle changes (for example, diet, exercise, quitting smoking), and regularly checking your blood sugar can help control your diabetes and improve your health. This therapy can also lower your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numbness, cold legs or feet; decreased sexual ability in men and women) , eye problems, including changes. or vision loss or gum disease. Your doctor and other healthcare providers will talk with you about the best way to control your diabetes.

How should this medicine be used?

Alogliptin comes as a tablet to take by mouth. It is usually taken with or without food once a day. Take alogliptin at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any parts you don’t understand. Take alogliptin exactly as directed. Do not take more or less, or take it more often than prescribed by your doctor.

Alogliptin controls diabetes but does not cure it. Keep taking alogliptin even if you feel fine. Do not stop taking alogliptin without consulting your doctor.

Your doctor or pharmacist will give you the manufacturer’s patient information sheet (Medication Guide) when you start treatment with alogliptin and each time you get a refill. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website ( or the manufacturer’s website to obtain the Medication Guide.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking alogliptin,

  • Tell your doctor and pharmacist if you are allergic to alogliptin; other DPP-4 inhibitors, including linagliptin (Tradjenta, in Glyxambi, in Jentadueto), saxagliptin (Onglyza, in Kombiglyze), sitagliptin (Januvia, in Janumet); any other medicine or any of the ingredients in alogliptin tablets. Ask your pharmacist or see the Medication Guide for a list of ingredients.
  • Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention insulin and other diabetes medications. Your doctor may need to change the doses of your medications or monitor you closely for side effects.
  • Tell your doctor if you drink or have ever drunk large amounts of alcohol and if you have or have ever had pancreatitis (swelling of the pancreas), gallstones, heart failure, or kidney or liver disease.
  • Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking alogliptin, call your doctor.
  • If you are having surgery, including dental surgery, tell the doctor or dentist that you are taking alogliptin.
  • Talk to your doctor about what to do if you hurt yourself or develop a fever or infection. These conditions can affect your blood sugar level and the amount of alogliptin you may need.

What special dietary instructions should I follow?

Be sure to follow all of the diet and exercise recommendations made by your doctor or dietitian. It is important to eat a healthy diet, exercise regularly, and lose weight if necessary. This will help control your diabetes and help alogliptin work more effectively.

What should I do if I forget a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for the one you forgot.

What side effects can this medication cause?

This medication may cause changes in your blood sugar. You should know the symptoms of high and low blood sugar and what to do if you develop these symptoms.

Alogliptin may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • headache
  • stuffy or runny nose
  • sore throat
  • joint pain

Some side effects can be serious. If you experience any of these symptoms, stop taking alogliptin and call your doctor immediately or get emergency medical treatment:

  • severe stomach pain that may move to your back
  • vomiting
  • excessive tiredness
  • loss of appetite
  • pain in the right upper area of the stomach
  • dark urine
  • yellowing of the skin or eyes
  • fever
  • blisters
  • skin peeling
  • rash
  • hives
  • itching
  • swelling of the eyes, face, lips, tongue, or throat
  • hoarseness
  • difficulty breathing or swallowing
  • shortness of breath, especially when lying down
  • swelling of the feet, ankles, or legs
  • sudden weight gain

Alogliptin may cause other side effects. Call your doctor if you have any unusual problems while taking this medicine.

If you experience a serious side effect, you or your doctor can submit a report online to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program ( or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medicine in the container it came in, tightly closed, and out of the reach of children. Store at room temperature and away from excess heat and moisture (not in the bathroom).

Unnecessary medications must be disposed of in special ways to ensure they cannot be consumed by pets, children, and others. However, you should not flush this medicine down the toilet. Instead, the best way to dispose of your medications is through a drug take-back program. Talk to your pharmacist or contact your local garbage / recycling department to find out about take-back programs in your community. See the FDA Safe Drug Disposal website ( for more information if you do not have access to a take-back program.

It is important to keep all medicines out of the sight and reach of children, since many containers (such as those containing weekly pills and those for eye drops, creams, patches and inhalers) are not resistant to children and small children can easily open them. To protect young children from poisoning, always close the safety caps and immediately place the medicine in a safe place, one that is upright and out of their sight and reach.

In case of emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim collapsed, had a seizure, is having trouble breathing, or cannot wake up, immediately call 911 for emergency services.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will likely order certain lab tests to check your body’s response to alogliptin. Your blood sugar and glycated hemoglobin (HbA1c) should be checked regularly to determine your response to alogliptin. Your doctor can also tell you how to check your response to alogliptin by measuring your blood or urine sugar levels at home. Follow these instructions carefully.

You should always wear a diabetic identification bracelet to ensure that you receive proper treatment in an emergency.

Do not let anyone else take your medicine. Ask your pharmacist any questions you have about refilling your prescription.

It is important that you keep a written list of all prescription and over-the-counter (over-the-counter) medications you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should take this list with you each time you visit a doctor or if you go into hospital. It is also important information to take with you in case of emergencies.

Brand Names

  • Nesina®

Brand names of combination products

  • Kazano® (containing Alogliptin, Metformin)
  • Oseni® (containing Alogliptin, Pioglitazone)

Disclaimer: We have made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.

Leave a Reply

Your email address will not be published. Required fields are marked *