Aliqopa : Uses, Side Effects, Interactions & More
Why is this medication prescribed?
Aliqopa (Copanlisib injection) is used to treat people with follicular lymphoma (FL; a slow-growing cancer of the blood) that has come back after being treated 2 or more times with other medicines. Aliqopa is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps stop or slow the spread of cancer cells.
How should this medicine be used?
Aliqopa (Copanlisib injection) comes as a powder that is mixed with liquid and is given through a needle or catheter that is placed into a vein. It is usually injected slowly over a 60-minute period on days 1, 8, and 15 of a 28-day treatment cycle.
Aliqopa can cause high blood pressure for up to 8 hours after the infusion. Your doctor will check your blood pressure before you receive the infusion and for several hours after the infusion is complete. If you experience any of the following symptoms after receiving the medicine, tell your doctor immediately: dizziness, feeling faint, headache, or pounding heartbeat.
Your doctor may reduce your dose, delay or stop your treatment with Aliqopa, or treat you with additional medications depending on your response to the medication and the side effects you experience. Talk to your doctor about how you feel during your treatment.
Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before receiving Aliqopa,
- Tell your doctor and pharmacist if you are allergic to copanlisib, any other medications, or any of the ingredients in Aliqopa. Ask your pharmacist for a list of the ingredients.
- Tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: boceprevir (Victrelis); carbamazepine (Carbatrol, Equetro, Tegretol, others), clarithromycin (Biaxin, in Prevpac), cobicistat (Tybost, in Evotaz, Genvoya, Prezcobix, Stribild), conivaptan (Vaprisol), diltiazem (Cardizem, Cartia, XT, others) efavirenz (Sustiva), enzalutamide (Xtandi), idelalisib (Zydelig), indinavir (Crixivan) with ritonavir; itraconazole (Sporonox, Onmel) and ketoconazole, lopinavir with ritonavir (in Kaletra); mitotane (Lysodren), nefazodone, nelfinavir (Viracept), nevirapine (Viramune), paritaprevir, ritonavir, ombitasvir, and / or dasabuvir (Viekira Pak); phenobarbital, phenytoin (Dilantin, Phenytek), posaconazole (Noxafil), rifabutin (Mycobutin), rifampin (Rifadine, in Rifamate, Rifater), ritonavir (Norvir, in Kaletra, Technivie, Viekira Pak), saquinavir, and tip Invirase) (Tipira Pakira) Aptivus) with ritonavir; and voriconazole (Vfend). Your doctor may need to change the doses of your medications or monitor you closely for side effects. Many other medications can also interact with Aliqopa, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.
- Tell your doctor what herbal products you are taking, especially St. John’s wort.
- Tell your doctor if you have an infection or if you have or have ever had high blood sugar, diabetes, lung or breathing problems, high blood pressure, or liver disease.
- Tell your doctor if you are pregnant, plan to become pregnant, or plan to have a child. You should not become pregnant while receiving Aliqopa. You will need to have a negative pregnancy test before you start receiving this medicine. Use effective birth control during your treatment with Aliqopa and for 1 month after your final dose. If you are a man and your partner can become pregnant, you must use effective contraception during your treatment and for 1 month after your last dose. If you or your partner become pregnant while receiving Aliqopa, call your doctor.
- Tell your doctor if you are breastfeeding. You should not breastfeed while receiving Aliqopa and for 1 month after your final dose.
- You should know that this medicine can decrease fertility in men and women. Talk to your doctor about the risks of receiving Aliqopa.
What special dietary instructions should I follow?
Do not drink grapefruit juice while receiving this medication.
Unless your doctor tells you otherwise, continue your normal diet.
What side effects can this medication cause?
Aliqopa may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- mouth sores, ulcers, or pain
- burning, prickling, tingling, or numb feeling on the skin
- pain upon touch
- swelling of nose, throat, or mouth
- lack of strength or energy
Some side effects can be serious. If you experience any of these symptoms call your doctor immediately:
- unusual bleeding or bruising
- new or worsening cough, shortness of breath, or difficulty breathing
- rash; or red, itching, peeling or swelling skin
- fever, sore throat, chills, or other signs of infection
- feeling very hungry or thirsty, headache, or frequent urination
Aliqopa may cause other side effects. Call your doctor if you have any unusual problems while receiving this medicine.
If you experience a serious side effect, you or your doctor can submit a report online to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What other information should I know?
Keep all appointments with your doctor and the laboratory. Your doctor will order certain laboratory tests to check your body’s response to Aliqopa.
Ask your pharmacist any questions you have about Aliqopa.
It is important that you keep a written list of all prescription and over-the-counter (over-the-counter) medications you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should take this list with you every time you visit a doctor or if you go into hospital. It is also important information to take with you in case of emergencies.
Disclaimer: We have made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.