Ajovy : Uses, Side Effects, Interactions & More

Why is this medication prescribed?

Ajovy (Fremanezumab-vfrm) injection is used to help prevent migraines (severe, throbbing headaches that are sometimes accompanied by nausea and sensitivity to sound or light). Ajovy injection is in a class of medications called monoclonal antibodies. It works by blocking the action of a certain natural substance in the body that causes migraines.

How should this medicine be used?

Ajovy (Fremanezumab-vfrm) injection comes as a solution (liquid) in a pre-filled syringe and as a pre-filled autoinjector to be injected subcutaneously (under the skin). It is usually given once a month (as 1 injection) or once every 3 months (as 3 separate injections, one after the other). Use Ajovy injection on about the same day every 1 to 3 month (s), depending on your dose. Follow the directions on your prescription label carefully and ask your doctor or pharmacist to explain any parts you do not understand. Use Ajovy injection exactly as directed. Do not use more or less or use it more often than prescribed by your doctor.

You may be able to inject the medicine yourself at home or ask a friend or family member to give you the injections. Ask your doctor to show you or the person who will be giving the injections how to inject the medicine.

Ajovy injection comes as a pre-filled syringe and a pre-filled autoinjector. Allow the syringe and autoinjector to warm up to room temperature for 30 minutes away from direct sunlight before injecting the medicine. Do not try to warm the medicine by heating it in a microwave, placing it in hot water, or by any other method. Use each syringe or autoinjector only once and inject all of the solution into the syringe or autoinjector. Dispose of used syringes or autoinjector in a puncture resistant container. Talk to your doctor or pharmacist about how to dispose of the puncture resistant container.

Inject Ajovy into the thigh, upper arm, or stomach area. Do not inject into an area where the skin is tender, thick, bruised, red, scaly, hard, or with scars or stretch marks.

Always look at Ajovy before injecting it. It should be clear and colorless. Do not use Ajovy injection if it is colored, cloudy, or contains flakes or solid particles. Do not shake it.

If your doctor tells you to inject three separate injections one after the other, use a different syringe or autoinjector for each injection. If you use the same site on the body (upper arm, thigh, or stomach) for separate injections, make sure that each injection is not in exactly the same place that it was used for the other injections.

Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before using Ajovy injection,

  • Tell your doctor and pharmacist if you are allergic to Ajovy, any other medications, or any of the ingredients in Ajovy injection. Ask your pharmacist for a list of the ingredients.
    tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Your doctor may need to change the doses of your medications or monitor you closely for side effects.
    tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using Ajovy injection, call your doctor.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

If you forget to inject your dose at the usual time, take it as soon as you remember. Then continue your dosing schedule from the date of your last dose.

What side effects can this medication cause?

Ajovy injection may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • injection site pain, swelling, or redness

Some side effects can be serious and may occur up to 1 month after you receive your injection. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

  • swelling of your face, mouth, tongue, or throat
  • difficulty breathing
  • rash
  • itching
  • hives

Ajovy injection may cause other side effects. Call your doctor if you have any unusual problems while receiving this medicine.

If you experience a serious side effect, you or your doctor can submit a report online to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medicine in the container it came in to protect from light, tightly closed, and out of the reach of children. Store it in the refrigerator, but do not freeze it. After removal from the refrigerator, the medicine can be stored in the original carton at room temperature for up to 24 hours. Discard Ajovy injection if it has been left at room temperature for more than 24 hours.

It is important to keep all medicines out of the sight and reach of children, as many containers (such as those containing weekly pills and those for eye drops, creams, patches and inhalers) are not child-resistant and small children can easily open them. To protect young children from poisoning, always close the safety caps and immediately place the medicine in a safe place, one that is upright and out of their sight and reach. http://www.upandaway.org

Unnecessary medications must be disposed of in special ways to ensure they cannot be consumed by pets, children, and others. However, you should not flush this medicine down the toilet. Instead, the best way to dispose of your medications is through a drug take-back program. Talk to your pharmacist or contact your local garbage / recycling department to learn about take-back programs in your community. Check out the FDA drug safe disposal website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim collapsed, had a seizure, is having trouble breathing, or is unable to wake up, immediately call 911 for emergency services.

What other information should I know?

Keep all your appointments with your doctor.

Don’t let anyone use your medicine. Ask your pharmacist any questions you have about refilling your prescription.

It is important that you keep a written list of all prescription and over-the-counter (over-the-counter) medications you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should take this list with you every time you visit a doctor or if you go into hospital. It is also important information to take with you in case of emergencies.

Brand Names

  • Ajovy®

Disclaimer: We have made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.

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