Aggrenox : Uses, Side Effects, Interactions & More

Why is this medication prescribed?

Aggrenox (Aspirin-Dipyridamole) belongs to a class of drugs called antiplatelet agents. It works by preventing excessive blood clotting. It is used to reduce the risk of stroke in patients who have had or are at risk of having a stroke.

How should this medicine be used?

Aggrenox (Aspirin-Dipyridamole) comes as capsules to take by mouth. It is usually taken twice a day, one capsule in the morning and one in the evening. Aggrenox should be swallowed whole. Do not open, crush, break or chew the capsules.

Follow the directions on your prescription label carefully and ask your doctor or pharmacist to explain any parts you do not understand. Take Aggrenox exactly as directed. Do not take more or less or take it more often than prescribed by your doctor.

Aggrenox reduces the risk of stroke, but does not eliminate that risk. Keep taking Aggrenox even if you feel fine. Don’t stop taking Aggrenox without talking to your doctor.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking Aggrenox,

  • Tell your doctor and pharmacist if you are allergic to aspirin, celecoxib (Celebrex), choline salicylate (Arthropan), diclofenac (Cataflam), diflunisal (Dolobid), dipyridamole (Persantine), etodolac (Lodine), fenoprofen (Nalfrofon) ( flurbipipene) Ansaid), ibuprofen (Advil, Motrin, Nuprin), indomethacin (Indocin), ketoprofen (Orudis, Oruvail), ketorolac (Toradol), magnesium salicylate (Nuprin Backache, Doan’s), meclofenamate, mefenamic acid, meloxicamonstel) (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn), oxaprozin (Daypro), piroxicam (Feldene), rofecoxib (Vioxx) (no longer available in the US), sulindac (Clinoril), tolmetin ( Tolectin) or any other medicine.
  • Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: acetazolamide (Diamox); ambenonium (Mytelase); Angiotensin converting enzyme inhibitors such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), quinapril (Accupril), ramipril (Altace) and trandolapril (Mavik); anticoagulants (‘blood thinners’) such as warfarin (Coumadin) and heparin; beta-blockers such as acebutolol (Sectral), atenolol (Tenormin), betaxolol (Kerlone), bisoprolol (Zebeta), carteolol (Cartrol), carvedilol (Coreg), labetalol (Normodyne), metoprolol (Lopressor), nadolol (Corgard), penbutol ), pindolol (Visken), propranolol (Inderal), sotalol (Betapace) and timolol (Blocadren); diabetes medications such as acetohexamide (Dymelor), chlorpropamide (Diabinese), glimepiride (Amaryl), glipizide (Glucotrol), glyburide (DiaBeta, Micronase, Glynase), repaglinide (Prandin), tolazamide (Tolinase), and tolbutamide (Orinase); diuretics (‘water pills’) such as amiloride (Midamor), bumetanide (Bumex), chlorothiazide (Diuril), chlorthalidone (Hygroton), ethacrynic acid (Edecrin), furosemide (Lasix), hydrochlorothiazide (Hydrodiuril), indapamide (Lozol) metolazone (Zaroxolyn), spironolactone (Aldactone), torsemide (Demadex), and triamterene (Dyrenium); methotrexate (Folex, Mexate, Rheumatrex); neostigmine (Prostigmin); non-steroidal anti-inflammatory drugs (NSAIDs) such as celecoxib (Celebrex), choline salicylate (Arthropan), diclofenac (Cataflam), diflunisal (Dolobid), etodolac (Lodine), fenoprofen (Nalfon), flurbiprofen (Ansaid), ibup, Motrin, Nalfrin (Ansaid), ibup, Motrin, others), indomethacin (Indocin), ketoprofen (Orudis, Oruvail), ketorolac (Toradol), magnesium salicylate (Nuprin Backache, Doan’s), meclofenamate, mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), naproxen ( Aleve, Naprosyn), oxaprozin (Daypro), piroxicam (Feldene), sulindac (Clinoril), and tolmetin (Tolectin); phenytoin (Dilantin); probenecid (Benemid); pyridostigmine (Mestinon); Sulfinpyrazone (Anturane); and valproic acid and related drugs (Depakene, Depakote).
  • Tell your doctor if you have or have ever had heart, kidney, or liver disease; a recent heart attack; bleeding disorders; low blood pressure; vitamin K deficiency; ulcers; the syndrome of asthma, rhinitis and nasal polyps; or if you drink three or more alcoholic drinks a day.
  • Tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while using Aggrenox, call your doctor immediately.
  • If you are having surgery, including dental surgery, tell the doctor or dentist that you are taking Aggrenox. Your doctor may tell you to stop taking Aggrenox before surgery.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet while taking Aggrenox.

What should I do if I forget a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for the one you forgot.

What side effects can this medication cause?

Side effects from Aggrenox can occur. Tell your doctor if any of these symptoms are severe or do not go away:

  • headache
  • heartburn
  • stomach pain
  • nausea
  • vomiting
  • diarrhea
  • muscle and joint pain
  • tiredness

If you experience any of the following symptoms, call your doctor immediately:

  • bleeding
  • severe rash
  • swelling of the lips, tongue, or mouth
  • difficulty breathing
  • warm feeling
  • flushing
  • sweating
  • restlessness
  • weakness
  • dizziness
  • chest pain
  • rapid heartbeat
  • ringing in the ears

If you experience a serious side effect, you or your doctor can submit a report online to the Food and Drug Administration’s (FDA) MedWatch Adverse Event Reporting program (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I know about storage and disposal of this medication?

Keep this medicine in the container it came in, tightly closed, and out of the reach of children. Store at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medicines out of the sight and reach of children, as many containers (such as those containing weekly pills and those for eye drops, creams, patches and inhalers) are not child-resistant and small children can easily open them. To protect young children from poisoning, always close the safety caps and immediately place the medicine in a safe place, one that is upright and out of their sight and reach. http://www.upandaway.org

Unnecessary medications must be disposed of in special ways to ensure that pets, children, and others cannot consume them. However, you should not flush this medicine down the toilet. Instead, the best way to dispose of your medications is through a drug take-back program. Talk to your pharmacist or contact your local garbage / recycling department to find out about take-back programs in your community. Check out the FDA drug safe disposal website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of emergency/overdose

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim collapsed, had a seizure, is having trouble breathing, or is unable to wake up, immediately call 911 for emergency services.

What other information should I know?

Do not substitute the single components of aspirin and dipyridamole (Persantine) for the Aggrenox product.

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your response to Aggrenox.

Do not let anyone else take your medicine. Ask your pharmacist any questions you have about refilling your prescription.

It is important that you keep a written list of all prescription and over-the-counter (over-the-counter) medications you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should take this list with you each time you visit a doctor or if you go into hospital. It is also important information to take with you in case of emergencies.

Brand names of combination products

  • Aggrenox® (containing Aspirin, Dipyridamole)

Disclaimer: We have made every effort to ensure that all information is factually accurate, comprehensive and up-to-date. However, this article should not be used as a licensed health care professional’s choice of knowledge and expertise. You should always consult your doctor or other health care professional before taking any medication. The information given here is subject to change and it has not been used to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions or adverse effects. The lack of warning or other information for any drug does not indicate that the combination of medicine or medication is safe, effective or appropriate for all patients or all specific uses.

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